Dr. Sandra Frazier attended medical school at The University of Mississippi, where she also completed a pediatric residency and fellowships in Adolescent Medicine and Addiction Medicine. She has been nationally certified in Addiction Medicine since 1991 and is currently a Fellow in the American Society of Addiction Medicine (ASAM).

She came to The University of Alabama at Birmingham (UAB) in 1994 and founded The Addiction Recovery Program in the Department of Psychiatry, where she served as Medical Director for 11 years. As part of this program, she worked with many health care professionals with substance use disorders and became interested in professional health and wellbeing, and decided to focus her efforts more broadly.

In an effort to assist health care providers in a more proactive and preventive way, she established The Professional Development Office in 2006 at UAB. For the last 19 years of her 31-year UAB career, her practice focused on caring for caregivers. As such, she worked with medical students, residents, fellows, Advanced Practice Providers, as well as MD and PhD faculty members to provide assessment, triage, counseling, and coaching all in a confidential setting.

In 2018, Dr Frazier became the Medical Director of the Alabama Professionals Health Program in a part-time role. Upon retirement from UAB in December of 2025, she stepped into the role full-time.